Craniopharyngioma Classification. Neurosurgical Forum
Autores: J.M. Pascual - Rodrigo Carrasco - Ruth Prieto - F. Gonzalez-Llanos - Fernando Alvarez - J.M. Roda
Abstract: We read with great interest the article by Kassam et al. (Kassam AB, Gardner PA, Snyderman CH, et al: expanded endonasal approach a fully transnasal appproach for the resection of midlinesuprasellar carniopharingyomas: a new classification based on the infundibulum . J. Neurosurg 108:715-728 April 2008).
Effectos of memantine and galantamine given separately or in association, on memory and hippocampal neuronal loss after transient global cerebral ischemia in gerbils.
Autores: Silvia Lorrio - Pilar Negredo - J.M. Roda - Antonio G.Garcia - Manuela G.Lopez
Abstract: Galantamine is an acetylcholinesterase inhibitor and memantine is a non competitiveantagonist of NMDA receptors that are being used to treat Alzheimer's disease (AD) patients.The fact that drugs with different mechanisms of action are available to treat AD introducesthe prospect of prescribing drug combinations to amplify drug efficacy....
Modelos experimentales de traumatismo craneoencefálico
Autores: R. Prieto - R. Gutierrez-Gonzalez - J.M. Pascual - J.M. Roda - S. Cerdán - J. Matias-Guiu - J.A. Barcia
Abstract: El objetivo de este trabajo es proporcionar una revisión de los diversos modelos experimentales de traumatismo craneoencefálico (TCE) que se han desarrollado para la investigación del daño cere-bral traumático tanto en condiciones in vivo como in vitro, así como detallar los principales conocimientos fisiopatológicos obtenidos a partir de su aplicación. Se expone de forma sintética tanto el tipo de lesión cerebral traumática que cada modelo reproduce como los detalles técnicos necesarios para su utilización por investigadores en el campo del trauma cerebral ...
Read Document PDF
Modelos experimentales de isquemia cerebral.
Autores: R.Prieto-Arribas - A.Moreno-Gutierrez - P.Simal-Hernandez - J.M.Pacual-Gravi - J.Matias-Guiu - J.M. Roda- -J.A.Barcia-Albacar
Abstract: La isquemia cerebral es el proceso fisiopatológico caracterizadopor la disfunción de una porción de tejido cerebral secundaria ala disminución del flujo en una arteria cerebral concreta. Se ma-nifiesta por la aparición súbita de déficits neurológicos transito-rios o permanentes. La evolución de la isquemia que persiste pordebajo de un umbral de flujo conlleva la necrosis del tejido y eldesarrollo de un infarto cerebral. En la población adulta de ma-yor edad la principal causa de los infartos isquémicos es la oclu-sión aterotrombótica o cardioembólica de una arteria cerebral ...
Time course of Early Metabolic Changes following Diffuse Traumatic Brain Injury in Rats as detected by H NMR Spectroscopy
Autores: J.M. Pascual - Juan Solivera - Ruth Prieto - Laura Barrios - Pilar Lopez-Larrubia - Sebastian Cerdan - J.M. Roda
Abstract: Experimental models of traumatic brains injury (TBI) provide a useful tool for understanding the cerebral metabolic changes induced by this pathological condition.
Here, we report on the timecourse of changes in cerebral metabolites after TBI and its correlation with early brain morpho-logical changes using a combination of high-resolution proton magnetic resonance spectroscopy (1HMRS) and magnetic resonance imaging (MRI). Adult male Sprague-Dawley rats were subjected toclosed head impact and examined by MRI at 1, 9, 24, 48, and and 72 h after the injury ...
Galantamine postischemia provides neuroprotection and memory recovery against transient global cerebral ischemia in gerbils
Autores: Silvia Lorrio - Monica Sobrado - Esperanza Arias - J.M. Roda - Antonio G.Garcia - Manuela G.Lopez
Abstract: Abstract: Galantamine, currently used in Alzheimer’s patients, has shownneuroprotection in hippocampal slices subjected to oxygen-glucose deprivation. Here, we present an in vivo study to eval-uate the potential neuroprotective effects of galantamine in atransient global cerebral ischemia model in gerbils. Three treatment protocols were used. In the pretreatment protocol, gerbils were treated before ischemia and for 3 consecutive days there-after. Eight groups of animals were included: sham operationplus placebo, 10 mg/kg mecamylamine and 10 mg/kg galantamine, respectively; and ischemia plus placebo, 10 mg/kgmecamylamine, 1 mg/kg galantamine, and 10 mg/kg galantamine and 10 mg/kg mecamylamine plus galantamine, respectively ...
Exitotoxicity and focal cerebral ischemoa induce truncation of the NR2A and NR2B subunitis of the NMDA receptor and cleavage of the scaffolding protein PSD-95
Autores: S. Gascon - M. Sobrado - J.M. Roda - A. Rodriguez-Peña - M. Diaz-Guerra
Abstract: The N-methyl-D-aspartate type of glutamate receptor(NMDAR) plays key roles in neuronal plasticity, learning and memory in the central nervous system,fundamentally due to its high Ca2þpermeability. However, inappropriate activation of the NMDAR isinvolved in the etiology of several human diseases. Particularly, overstimulation of the NMDARs by agonists can induce excitotoxic cell death and contribute to neuronal degeneration in different disorders, including acute insults such as hypoxia.
Transcription of the NR1 Subunit of the N-Methyl- d-aspartate receptor is down-regulated by Exitotoxic stimulation and cerebral ischemia.
Autores: Sergio Gascon - Ruben Deogracias - Monica Sobrado - J.M. Roda - Jaime Renart - Angeles Rodriguez-Peña - Margarita Diaz-Guerra
Abstract: The N-Methyl-d-aspartate type of glutamate receptor plays central roles