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Glutamate, glutamine, and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats.

Autores: J.M. Pascual - Fernando Carceller - J.M. Roda -  Sebastian Cerdan

Abstract: Some of the metabolic mechanisms underlying the devel-opment of ischemic brain damage have been investigated using highly enriched cultures of neural cells1– 4or cerebral cortex slices. However, the metabolic events occurring in vivo in the neuronal and glial compartments of the adult brain during the development of ischemic damage remain less understood. ...

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DNA methylation of multiple genes in vestibular schawannoma: relationship with clinical and radiological findings.

Autores: Luis Lassaletta - M. Josefa Bello - Laura del Rio - Carolina Alfonso - J.M. Roda - Juan A. Rey - Javier Gavilan

Abstract: Vestibular schwannomas (VSs) are common benign tumors accounting for 8Y10% of intracranial tumors and about 80% of cerebellopontine tumors. Histologically, VSs arise from the sheath of the eight nerve. These tumors generally grow slowly, causing minimal symptoms at the time of diagnosis. The growth rate of VS is known to be extremely variable, with most tumors showing slow growth for many years.

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Effect of combined therapy with thrombolisys and citicoline in a rat model  of embolic stroke.

Autores: Maria Alonso de Leciñana - Maria Gutierrez - J.M. Roda - Fernando Carceller - Exuperio Diez-Tejedor

Abstract: An approach combining reperfusion mediated by thormbolitycs with pharmacological neuroprotection aimed in inhibiting the phisiopathological disorders responsible for schemia-reperfusion damage, could provide an optimal treatment of ischemic stroke.

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Can cholinesterase inhibitors provide additional effects to cholinergic neurotransmission enhancement?.

Autores: Manuela G.Lopez - Esperanza Arias - Monica Sobrado - Silvia Lorrio - J.M. Roda - Antonio G.Garcia

Abstract: The most frequent of the primary degenerative dementias ...

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New goals in ischemic stroke therapy: the experimental approach harmonizing science with practice.

Autores: M. Alonso de Leciñana- -E. Diez-Tejedor - Maria Gutierrez - Sandra Guerrero - Fernando Carceller - J.M. Roda

Abstract: Undeniable advances have been made in clinical and experimental investigation ...

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Bases Anatomicas y Hemodinamicas del complejo de la arteria comunicante anterior.

Autores: F. Gonzalez-Llanos - J.M. Pascual - J.M. Roda

Abstract: El complejo de la arteria comunicante anterior constituye la localizacion mas frecuente de aneurismas cerebrales y se caracteriza por su gran numero de variantes anatomicas.

La presencia de aneurismas de la arteria comunicante anterior se ha asociado a la existencia de una asimetría de este complejo.

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La barrera hematoencefalica: desarrollo de una estructura que permite la heterogeneidad funcional del sistema nervioso central.

Autores: J.M. Pascual-Garvi - F. Gonzalez-Llanos - R. Prieto-Arribas - S. Cerdan - J.M. Roda

Abstract: El sistema nervioso central (SNC) requiere para su funcionamiento de un aporte continuo de sustratos energéticos –fundamentalmente oxígeno y glucosa–, suministrados a través de una riquísima red de capilares sanguíneos, probablemente la más compleja del organismo.

Sin embargo, y aparentemente de forma paradójica, el medio interno del SNC se encuentra aislado con respecto a la circulación sanguínea por una estructura también única en el organismo: la denominada barrera hematoencefálica (BHE) [1-4] .

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Intraventricular craniopharyngiomas: topographical classification and surgical approach selection based on an extensive overview

Autores: J.M.Pascual - F. Gonzalez-Llanos - L. Barrios - J.M. Roda

Abstract: Since 1953, when Dobos described a craniopharyn-gioma wholly located in the third ventricle for the first time [19], there have been a few additional cases which were diagnosed at necropsy, proving the undoubted existence of this particular and rare location. In these necropsy brain specimens the tumor was hidden from outside view, and the third ventricle floor was intact[7, 8, 13, 14, 19, 33, 34, 45–47, 57]. They were named intraventricular craniopharyngiomas (IVC). Their topo-graphical location challenged the embryological theory about craniopharyngioma development, since there was no obvious pathway ascent of Rathke’s pouch-derived epithelial cells to the third ventricle cavity.

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Galantamine and memantine produce different degrees of neuroprotection in rat hippocampal slices subjected to oxygen-glucose deprivation.

Autores: Monica Sobrado - J.M. Roda - Manuela G.Lopez - Javier Egea - Antonio G.Garcia

Abstract: Recent clinical trials show therapeutic benefits in cognition, ...

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Hemangioblastoma of the lateral ventricle: case report and review of the literature.

Autores: R. Prieto - J.M. Roda

Abstract: En este trabajo describimos el caso de un paciente de 73 años con deficits cognitivos y disfasa sensitiva y que fue diagnosticado mediante tomografia .....

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