Curso temporal de los cambios metabolicos en traumatismo craneoencefalico experimental

Time course  of Early Metabolic Changes following Diffuse Traumatic Brain Injury  in Rats  as detected by H NMR Spectroscopy

Autores: J.M. Pascual - Juan Solivera - Ruth Prieto - Laura Barrios - Pilar Lopez-Larrubia - Sebastian Cerdan - J.M. Roda

Abstract: Experimental models of traumatic brains injury (TBI) provide a useful tool for understanding the cerebral metabolic changes induced by this pathological condition.

Here, we report on the timecourse of changes in cerebral metabolites after TBI and its correlation with early brain morpho-logical changes using a combination of high-resolution proton magnetic resonance spectroscopy (1HMRS) and magnetic resonance imaging (MRI). Adult male Sprague-Dawley rats were subjected toclosed head impact and examined by MRI at 1, 9, 24, 48, and and 72 h after the injury ...

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