A petición del Presidente de la Sociedad Española de Neurocirugía, nos complace enviar al Dr. José Mª Roda una carta de agradecimiento como motivo de la Reunión conjunta del XVI Congreso Nacional de la Sociedad Española de Neurocirugía (SENEC) y el Congress of Neurological Surgeons (CNS) celebrada en Madrid del 24 al 27 de mayo de 2011.
Human Cadaver brain infusion skull model for neurosurgical training.
Autores: J.Olabe Goxencia - Javier Olabe - J.M. Roda - Vidal Sancho
Abstract: Microsurgical technique and anatomical knowledge require extensive laboratory training. Human cadaver models are especially valuable as they supply a good microsurgical training environment simultaneously providing authentic brain anatomy. We developed the “skull infusion model” as an extension of our previous “brain infusion model” taking it a step further maintaining simplicity but enhancing realism ...
Functional recovery after hematic administration of allogenic mesenchimal stem cells in acute schemic stroke in rates.
Autores: M. Gutierrez-Fernandez - B. Rodriguez-Frutos - J. Alvarez-Grech - M.T. vallejo-Cremades - M. Exposito-Alcaide - J. Merino - J.M. Roda - E. Diez-Tejedor
Abstract: The majority of neuroprotective treatments for cerebral ischemia have been efficacious in experimental studies but have failed their clinical trials. Abstract: The majority of neuroprotective treatments for cerebral ischemia have been efficacious in experimental studies but have failed their clinical trials. Only i.v. thrombolysis (rtPA) hasbeen shown to be effective; however its narrow therapeutictime window makes it a treatment for a reduced percentageof patients (Hacke et al., 2008). In the past, protective ther-apies have been directed towards saving neural cells. Stroke-induced damage compromises the integrity of the neurovas-cular unit (Lo et al., 2003) through various pathophysiologicmechanisms. Angiogenesis, neurogenesis and synaptogen-esis are interrelated mechanisms that promote brain plasticityand help to repair the neurovascular unit and recover neuro-logical function (Gutierrez et al., 2009). Endogenous brainplasticity can be stimulated by rehabilitation, stimulationand/or administration of trophic factors and cell therapy.
Microsurgical cerebral aneurysm training porcine model
Autores: Jon Olabe - Javier Olabe - J.M. Roda
Abstract: The authors developed a simple reproducible technique for aneurysm creation and adapted it to mimic intracranial dissection conditions using glue application as a pseudo-arachnoid type layer. Ten 1–2-month-old healthy domestic swine were employed under general anesthesia. A novel technique for bifurcation aneurysm creation was developed using two arteries and a vein. After aneurysm creation, diluted sulfuric acid was applied on the dome with a micropipette to increase aneurysm fragility in selected zones.
¿Como reparar el daño cerebral isquémico?. Utilidad de los modelos experimentales en la búsqueda de respuestas.
Autores: R. Prieto Arribas, J.M. Pascual-Garvi, F. Gonzalez-LLanos, J.M. Roda
Abstract: "Las neuronas son las misteriosas mariposas del alma, cuyo batir de las alas quien sabe si esclarecerán algun dia el secreto de la vida mental". Santiagfo Ramón y Cajal (1852-1934).
Existe una polémica creciente en torno a la utilidad clínica de los modelos experimentales de isquemia cerebral, alimentada por la discrepancia observada entre los estudios experimentales y los ensayos clínicos respecto a la eficacia de las terapias que tratan de aminorar o revertir el daño isquémico cerebral. Más de dos décadas de intenso trabajo que abarcan miles de estudios experimentales y cientos de estudios clínicos con un coste global de billones de dólares parecen baldíos, al no haberse hallado ninguna terapia efectiva capaz de aminorar el daño isquémico cerebral, a excepción de la terapia trombolítica con factor activador del plasminógeno, que se estima aplicable a tan sólo un 5% de los pacientes admitidos y diagnosticados de un ictus en la urgencia hospitalaria. ¿Debemos por ello concluir que los modelos experimentales de isquemia cerebral son irrelevantes para el dise no y ensayo de terapias farmacológicas ...
Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer...
Autores: Abdelouhahid Samadi - Jose Marco-Contelles - Elena Soriano - Monica Alvarez-Perez - Mourad Chioua - Alejandro Romero - Laura Gonzalez-Lafuente - Luis Gandía - Jose Maria Roda - Manuela G. Lopez - Mercedes Villaroya - Antonio G. Garcia - Cristobal de los Rios
Abstract: Alzheimer’s disease (AD) is an age-related neurodegenerative process characterized by a progressive loss of cognitive abilities, such as memory, language skills, disorientation, attention, and depression. Although the etiology of AD is still poorly understood, several factors such as amyloid-b (Ab)2 deposits, s-protein aggregation, oxidative stress or low levels of acetylcholine3 are thought to play significant roles in the pathology of the disease.4 In spite of the enormous research effort, an efficient strategy for designing new drugs for the treatment of AD is still lacking.
The cholinergic theory1suggests that the selective loss of cho-linergic neurons in AD results in a deficit of acetylcholine (ACh)in specific regions of the brain that mediate learning and memory functions. Consequently, three acetylcholinesterase (AChE) inhib-itors have been approved for commercial use...
Fistulas de LCR tras la cirugia de tumores del angulo pontocerebeloso y su relacion con el indice de masa corporal
Autores: Agueda Diaz Anadon - Luis Lassaletta - J.M. Roda - Javier Gavilan Bouzas
Abstract: La cirugia del schwannoma vestibular (SV) se inció a finales del siglo XIX. En esa epoca ... se caracterizaba por una elevada morbimortalidad llegando la mortalidad a superar el 20%. Gracias a los avances de las tecnicas quirurgicas, la mortalidad de esta cirugia ha descendido considerablemente, consiguiendose la reseccion tumoral completa y la conservacion de las funciones facial y auditiva en no pocos casos. Una de las complicaciones provocadas por esta cirugia, la mas frecuente en la mayorıa de las series, es la fistula de liquido cefalorraquıdeo (LCR)
Assessment of P-NMR analysis of phospholipid profiles for potential differential diagnosis of human cerebral tumors.
Autores: Juan Solivera - Sebastian Cerdan - J.M.Pascual - Laura Barrios - J.M. Roda
Abstract: Magnetic resonance spectroscopy (MRS) offers a variety of procedures to assess the metabolic alterations that occur in cerebral neoplasms, helping to obtain diagnostic decisions in a manner complementary to that provided by classical histopathology. H-MRS has been most widely used in this context, in combination with elaborate statistical approaches, to classify the histological type of the brain tumor and its grade of malignancy. These studies are mainly focused in the profile of water soluble metabolites in vivo or ex vivo, as detected by H MRS or H HRMAS (high-resolution magic angle spinning) ...
H HR-MAS and genomic analisys of human tumor biopsies discriminate between high and low grade astrocytomas
Autores: Valeria Righi - J.M. Roda - Jose Paz - Adela Mucci - Vitaliano Tugnoli - Gemma Rodriguez-Tarduchy - Laura Barrios - Luisa Schenetti - Sebastian Cerdan - Maria L. Garcia-Martin
Abstract: Discrimination between high and low glioma grade remains avital diagnostic decision, determining the most effective treatment and having an important impact on patient manage-ment and outcome .In vivo HMR spectroscopic examinations are often used in clinical environments to assess tumor aggressiveness and help the MRI-based tumor diagnosis. Auseful parameter in this sense is the total Choline (tCho) versus Creatine (Cr) ratio, which has previously been reported to be related to tumor grade. ...
Effects of memantine and galantamine given separately or in association, on memory and hippocampal neuronal loss after transient global cerebral ischemia in gerbils.
Autores: Silvia Lorrio - Pilar Negredo - J.M. Roda - A.G.Garcia - Manuela G.Lopez
Abstract: Galantamine is an acetylcholinesterase inhibitor and memantine is a non competitive antagonist of NMDA receptors that are being used to treat Alzheimer's disease (AD) patients.The fact that drugs with different mechanisms of action are available to treat AD introduces the prospect of prescribing drug combinations to amplify drug efficacy. This study wasplaned to evaluate the potential neuroprotective effects of galantamine combined with memantine in a transient global cerebral ischemia model in gerbils. ....