Exitotoxicity and focal cerebral ischemoa induce truncation of the NR2A and NR2B subunitis of the NMDA receptor and cleavage of the scaffolding protein PSD-95
Autores: S. Gascon - M. Sobrado - J.M. Roda - A. Rodriguez-Peña - M. Diaz-Guerra
Abstract: The N-methyl-D-aspartate type of glutamate receptor(NMDAR) plays key roles in neuronal plasticity, learning and memory in the central nervous system,fundamentally due to its high Ca2þpermeability. However, inappropriate activation of the NMDAR isinvolved in the etiology of several human diseases. Particularly, overstimulation of the NMDARs by agonists can induce excitotoxic cell death and contribute to neuronal degeneration in different disorders, including acute insults such as hypoxia.