Categoría: Publicaciones

Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer...

Autores: Abdelouhahid Samadi - Jose Marco-Contelles - Elena Soriano - Monica Alvarez-Perez - Mourad Chioua - Alejandro Romero - Laura Gonzalez-Lafuente - Luis Gandía - Jose Maria Roda - Manuela G. Lopez - Mercedes Villaroya - Antonio G. Garcia - Cristobal de los Rios

Abstract: Alzheimer’s disease (AD) is an age-related neurodegenerative process characterized by a progressive loss of cognitive abilities, such as memory, language skills, disorientation, attention, and depression. Although the etiology of AD is still poorly understood, several factors such as amyloid-b (Ab)2 deposits, s-protein aggregation, oxidative stress or low levels of acetylcholine3 are thought to play significant roles in the pathology of the disease.4 In spite of the enormous research effort, an efficient strategy for designing new drugs for the treatment of AD is still lacking.

The cholinergic theory1suggests that the selective loss of cho-linergic neurons in AD results in a deficit of acetylcholine (ACh)in specific regions of the brain that mediate learning and memory functions. Consequently, three acetylcholinesterase (AChE) inhib-itors have been approved for commercial use...

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Fistulas de LCR tras la cirugia de tumores del angulo pontocerebeloso y su relacion con el indice de masa corporal

Autores: Agueda Diaz Anadon - Luis Lassaletta - J.M. Roda - Javier Gavilan Bouzas

Abstract: La cirugia del schwannoma vestibular (SV) se inció a finales del siglo XIX. En esa epoca ... se caracterizaba por una elevada morbimortalidad llegando la mortalidad a superar el 20%. Gracias a los avances de las tecnicas quirurgicas, la mortalidad de esta cirugia ha descendido considerablemente, consiguiendose la reseccion tumoral completa y la conservacion de las funciones facial y auditiva en no pocos casos. Una de las complicaciones provocadas por esta cirugía, la mas frecuente en la mayorıa de las series, es la fístula de líquido cefalorraquıdeo (LCR)

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Assessment of P-NMR analysis of phospholipid profiles for potential differential diagnosis of human cerebral tumors.

Autores: Juan Solivera - Sebastian Cerdan - J.M.Pascual - Laura Barrios - J.M. Roda

Abstract: Magnetic resonance spectroscopy (MRS) offers a variety of procedures to assess the metabolic alterations that occur in cerebral neoplasms, helping to obtain diagnostic decisions in a manner complementary to that provided by classical histopathology. H-MRS has been most widely used in this context, in combination with elaborate statistical approaches, to classify the histological type of the brain tumor and its grade of malignancy. These studies are mainly focused in the profile of water soluble metabolites in vivo or ex vivo, as detected by H MRS or H HRMAS (high-resolution magic angle spinning) ...

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H HR-MAS and genomic analisys of human tumor biopsies discriminate between high and low grade astrocytomas

Autores: Valeria Righi - J.M. Roda - Jose Paz - Adela Mucci - Vitaliano Tugnoli - Gemma Rodriguez-Tarduchy - Laura Barrios - Luisa Schenetti - Sebastian Cerdan - Maria L. Garcia-Martin

Abstract: Discrimination between high and low glioma grade remains avital diagnostic decision, determining the most effective treatment and having an important impact on patient manage-ment and outcome .In vivo HMR spectroscopic examinations are often used in clinical environments to assess tumor aggressiveness and help the MRI-based tumor diagnosis. Auseful parameter in this sense is the total Choline (tCho) versus Creatine (Cr) ratio, which has previously been reported to be related to tumor grade. ...

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Effects of memantine and galantamine given separately or in association, on memory and hippocampal neuronal loss after transient global cerebral ischemia in gerbils.

Autores: Silvia Lorrio -  Pilar Negredo - J.M. Roda - A.G.Garcia - Manuela G.Lopez

Abstract: Galantamine is an acetylcholinesterase inhibitor and memantine is a non competitive antagonist of NMDA receptors that are being used to treat Alzheimer's disease (AD) patients.The fact that drugs with different mechanisms of action are available to treat AD introduces the prospect of prescribing drug combinations to amplify drug efficacy. This study wasplaned to evaluate the potential neuroprotective effects of galantamine combined with memantine in a transient global cerebral ischemia model in gerbils. ....

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Craniopharyngioma Classification. Neurosurgical Forum

Autores: J.M. Pascual - Rodrigo Carrasco - Ruth Prieto - F. Gonzalez-Llanos - Fernando Alvarez - J.M. Roda

Abstract: We read with great interest the article by Kassam et al. (Kassam AB, Gardner PA, Snyderman CH,  et al: expanded endonasal approach a fully transnasal appproach for the resection of midlinesuprasellar carniopharingyomas: a new classification based on the infundibulum . J. Neurosurg 108:715-728 April 2008).

In their paper Kassam and colleagues introduced a newtopographical classification of craniopharyngiomas that isbased on the relationships of the tumor to the infundibulumand pituitary stalk, as observed in the surgical field by en-doscopic viewing...

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Effectos of memantine and galantamine given separately or in association, on memory and hippocampal neuronal loss after transient global cerebral ischemia in gerbils.

Autores: Silvia Lorrio - Pilar Negredo - J.M. Roda - Antonio G.Garcia - Manuela G.Lopez

Abstract: Galantamine is an acetylcholinesterase inhibitor and memantine is a non competitiveantagonist of NMDA receptors that are being used to treat Alzheimer's disease (AD) patients.The fact that drugs with different mechanisms of action are available to treat AD introducesthe prospect of prescribing drug combinations to amplify drug efficacy ....

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Modelos experimentales de traumatismo craneoencefálico

Autores: R. Prieto - R. Gutierrez-Gonzalez - J.M. Pascual - J.M. Roda - S. Cerdán - J. Matias-Guiu - J.A. Barcia

Abstract: El objetivo de este trabajo es proporcionar una revisión de los diversos modelos experimentales de traumatismo craneoencefálico (TCE) que se han desarrollado para la investigación del daño cere-bral traumático tanto en condiciones in vivo como in vitro, así como detallar los principales conocimientos fisiopatológicos obtenidos a partir de su aplicación. Se expone de forma sintética tanto el tipo de lesión cerebral traumática que cada modelo reproduce como los detalles técnicos necesarios para su utilización por investigadores en el campo del trauma cerebral ...

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Modelos experimentales  de isquemia cerebral.

Autores: R.Prieto-Arribas - A.Moreno-Gutierrez - P.Simal-Hernandez - J.M.Pacual-Gravi - J.Matias-Guiu - J.M. Roda - J.A.Barcia-Albacar

Abstract: La isquemia cerebral es el proceso fisiopatológico caracterizadopor la disfunción de una porción de tejido cerebral secundaria ala disminución del flujo en una arteria cerebral concreta. Se ma-nifiesta por la aparición súbita de déficits neurológicos transito-rios o permanentes. La evolución de la isquemia que persiste pordebajo de un umbral de flujo conlleva la necrosis del tejido y eldesarrollo de un infarto cerebral. En la población adulta de ma-yor edad la principal causa de los infartos isquémicos es la oclu-sión aterotrombótica o cardioembólica de una arteria cerebral ...

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Cyclin D1 expression and histophatologic features in vestibualr schwannoma

Autores: Luis Lassaletta - M. Josefa Bello - Laura del Rio - Carolina Alfonso - J.M. Roda - Juan A. Rey - Javier Gavilan

Abstract: The molecular changes involved in the pathogenesisof vestibular schwannoma (VS) have been studied inpast years. Most studies have focused on the moleculargenetic analysis of the NF2gene. Inactivation of merlin,the product of the NF2tumor suppressor gene, is responsible for VS development both in sporadic and bilateralcases. Epigenetic changes have also been described in several genes, some of them with clinical implicationson VS behavior.

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