Categoría: Publicaciones

Time course  of Early Metabolic Changes following Diffuse Traumatic Brain Injury  in Rats  as detected by H NMR Spectroscopy

Autores: J.M. Pascual - Juan Solivera - Ruth Prieto - Laura Barrios - Pilar Lopez-Larrubia - Sebastian Cerdan - J.M. Roda

Abstract: Experimental models of traumatic brains injury (TBI) provide a useful tool for understanding the cerebral metabolic changes induced by this pathological condition.

Here, we report on the timecourse of changes in cerebral metabolites after TBI and its correlation with early brain morpho-logical changes using a combination of high-resolution proton magnetic resonance spectroscopy (1HMRS) and magnetic resonance imaging (MRI). Adult male Sprague-Dawley rats were subjected toclosed head impact and examined by MRI at 1, 9, 24, 48, and and 72 h after the injury ...

Leer Documento PDF

Galantamine postischemia provides neuroprotection and memory recovery against transient global cerebral ischemia in gerbils

Autores: Silvia Lorrio - Monica Sobrado - Esperanza Arias - J.M. Roda - Antonio G.Garcia - Manuela G.Lopez

Abstract: Galantamine, currently used in Alzheimer’s patients, has shownneuroprotection in hippocampal slices subjected to oxygen-glucose deprivation. Here, we present an in vivo study to eval-uate the potential neuroprotective effects of galantamine in atransient global cerebral ischemia model in gerbils. Three treatment protocols were used. In the pretreatment protocol, gerbils were treated before ischemia and for 3 consecutive days there-after. Eight groups of animals were included: sham operationplus placebo, 10 mg/kg mecamylamine and 10 mg/kg galantamine, respectively; and ischemia plus placebo, 10 mg/kgmecamylamine, 1 mg/kg galantamine, and 10 mg/kg galantamine and 10 mg/kg mecamylamine plus galantamine, respectively ...

Leer Documento PDF

Exitotoxicity and focal cerebral ischemoa induce truncation of the NR2A and NR2B subunitis of the NMDA receptor and cleavage of the scaffolding protein PSD-95

Autores: S. Gascon - M. Sobrado - J.M. Roda - A. Rodriguez-Peña - M. Diaz-Guerra

Abstract: The N-methyl-D-aspartate type of glutamate receptor(NMDAR) plays key roles in neuronal plasticity, learning and memory in the central nervous system,fundamentally due to its high Ca2þpermeability. However, inappropriate activation of the NMDAR isinvolved in the etiology of several human diseases. Particularly, overstimulation of the NMDARs by agonists can induce excitotoxic cell death and contribute to neuronal degeneration in different disorders, including acute insults such as hypoxia.

Leer Documento PDF

Exitotoxicity and focal cerebral ischemoa induce truncation of the NR2A and NR2B subunitis of the NMDA receptor and cleavage of the scaffolding protein PSD-95

Autores: S. Gascon - M. Sobrado - J.M. Roda - A. Rodriguez-Peña - M. Diaz-Guerra

Abstract: The N-Methyl-D-aspartate type of glutamate receptor (NMDAR) plays key roles in neuronal plasticity, learning and memory in the central nervous system, fundamentally due to its high Ca2+ permeability.

Leer Documento PDF

Glutamate, glutamine, and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats.

Autores: J.M. Pascual - Fernando Carceller - J.M. Roda -  Sebastian Cerdan

Abstract: Some of the metabolic mechanisms underlying the devel-opment of ischemic brain damage have been investigated using highly enriched cultures of neural cells1– 4or cerebral cortex slices. However, the metabolic events occurring in vivo in the neuronal and glial compartments of the adult brain during the development of ischemic damage remain less understood. ...

Leer Documento PDF

DNA methylation of multiple genes in vestibular schawannoma: relationship with clinical and radiological findings.

Autores: Luis Lassaletta - M. Josefa Bello - Laura del Rio - Carolina Alfonso - J.M. Roda - Juan A. Rey - Javier Gavilan

Abstract: Vestibular schwannomas (VSs) are common benign tumors accounting for 8Y10% of intracranial tumors and about 80% of cerebellopontine tumors. Histologically, VSs arise from the sheath of the eight nerve. These tumors generally grow slowly, causing minimal symptoms at the time of diagnosis. The growth rate of VS is known to be extremely variable, with most tumors showing slow growth for many years.

Leer Documento PDF

Effect of combined therapy with thrombolisys and citicoline in a rat model  of embolic stroke.

Autores: Maria Alonso de Leciñana - Maria Gutierrez - J.M. Roda - Fernando Carceller - Exuperio Diez-Tejedor

Abstract: An approach combining reperfusion mediated by thormbolitycs with pharmacological neuroprotection aimed in inhibiting the phisiopathological disorders responsible for schemia-reperfusion damage, could provide an optimal treatment of ischemic stroke.

Leer Documento PDF

Can cholinesterase inhibitors provide additional effects to cholinergic neurotransmission enhancement?.

Autores: Manuela G.Lopez - Esperanza Arias - Monica Sobrado - Silvia Lorrio - J.M. Roda - Antonio G.Garcia

Abstract: The most frequent of the primary degenerative dementias ...

Leer Documento PDF

New goals in ischemic stroke therapy: the experimental approach harmonizing science with practice.

Autores: M. Alonso de Leciñana- -E. Diez-Tejedor - Maria Gutierrez - Sandra Guerrero - Fernando Carceller - J.M. Roda

Abstract: Undeniable advances have been made in clinical and experimental investigation ...

Leer Documento PDF

Transcription of the NR1 Subunit of the N-Methyl- d-aspartate receptor is down-regulated by Exitotoxic stimulation and cerebral ischemia.

Autores: Sergio Gascon - Ruben Deogracias - Monica Sobrado - J.M. Roda - Jaime Renart - Angeles Rodriguez-Peña - Margarita Diaz-Guerra

Abstract: The N-Methyl-d-aspartate type of glutamate receptor plays central roles

Leer Documento PDF