Effectos of memantine and galantamine given separately or in association, on memory and hippocampal neuronal loss after transient global cerebral ischemia in gerbils.
Autores: Silvia Lorrio - Pilar Negredo - J.M. Roda - Antonio G.Garcia - Manuela G.Lopez
Abstract: Galantamine is an acetylcholinesterase inhibitor and memantine is a non competitiveantagonist of NMDA receptors that are being used to treat Alzheimer's disease (AD) patients.The fact that drugs with different mechanisms of action are available to treat AD introducesthe prospect of prescribing drug combinations to amplify drug efficacy ....