Curso temporal de los cambios metabolicos en traumatismo craneoencefalico experimental
Time course of Early Metabolic Changes following Diffuse Traumatic Brain Injury in Rats as detected by H NMR Spectroscopy
Autores: J.M. Pascual - Juan Solivera - Ruth Prieto - Laura Barrios - Pilar Lopez-Larrubia - Sebastian Cerdan - J.M. Roda
Abstract: Experimental models of traumatic brains injury (TBI) provide a useful tool for understanding the cerebral metabolic changes induced by this pathological condition.
Here, we report on the timecourse of changes in cerebral metabolites after TBI and its correlation with early brain morpho-logical changes using a combination of high-resolution proton magnetic resonance spectroscopy (1HMRS) and magnetic resonance imaging (MRI). Adult male Sprague-Dawley rats were subjected toclosed head impact and examined by MRI at 1, 9, 24, 48, and and 72 h after the injury ...
La galantamina protege en isquemia cerebral
Galantamine postischemia provides neuroprotection and memory recovery against transient global cerebral ischemia in gerbils
Autores: Silvia Lorrio - Monica Sobrado - Esperanza Arias - J.M. Roda - Antonio G.Garcia - Manuela G.Lopez
Abstract: Galantamine, currently used in Alzheimer’s patients, has shownneuroprotection in hippocampal slices subjected to oxygen-glucose deprivation. Here, we present an in vivo study to eval-uate the potential neuroprotective effects of galantamine in atransient global cerebral ischemia model in gerbils. Three treatment protocols were used. In the pretreatment protocol, gerbils were treated before ischemia and for 3 consecutive days there-after. Eight groups of animals were included: sham operationplus placebo, 10 mg/kg mecamylamine and 10 mg/kg galantamine, respectively; and ischemia plus placebo, 10 mg/kgmecamylamine, 1 mg/kg galantamine, and 10 mg/kg galantamine and 10 mg/kg mecamylamine plus galantamine, respectively ...
Excitotoxicidad e isquemia cerebral
Exitotoxicity and focal cerebral ischemoa induce truncation of the NR2A and NR2B subunitis of the NMDA receptor and cleavage of the scaffolding protein PSD-95
Autores: S. Gascon - M. Sobrado - J.M. Roda - A. Rodriguez-Peña - M. Diaz-Guerra
Abstract: The N-methyl-D-aspartate type of glutamate receptor(NMDAR) plays key roles in neuronal plasticity, learning and memory in the central nervous system,fundamentally due to its high Ca2þpermeability. However, inappropriate activation of the NMDAR isinvolved in the etiology of several human diseases. Particularly, overstimulation of the NMDARs by agonists can induce excitotoxic cell death and contribute to neuronal degeneration in different disorders, including acute insults such as hypoxia.