Exitotoxicity and focal cerebral ischemoa induce truncation of the NR2A and NR2B subunitis of the NMDA receptor and cleavage of the scaffolding protein PSD-95

Autores: S. Gascon - M. Sobrado - J.M. Roda - A. Rodriguez-Peña - M. Diaz-Guerra

Abstract: The N-Methyl-D-aspartate type of glutamate receptor (NMDAR) plays key roles in neuronal plasticity, learning and memory in the central nervous system, fundamentally due to its high Ca2+ permeability.

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Glutamate, glutamine, and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats.

Autores: J.M. Pascual - Fernando Carceller - J.M. Roda -  Sebastian Cerdan

Abstract: Some of the metabolic mechanisms underlying the devel-opment of ischemic brain damage have been investigated using highly enriched cultures of neural cells1– 4or cerebral cortex slices. However, the metabolic events occurring in vivo in the neuronal and glial compartments of the adult brain during the development of ischemic damage remain less understood. ...

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DNA methylation of multiple genes in vestibular schawannoma: relationship with clinical and radiological findings.

Autores: Luis Lassaletta - M. Josefa Bello - Laura del Rio - Carolina Alfonso - J.M. Roda - Juan A. Rey - Javier Gavilan

Abstract: Vestibular schwannomas (VSs) are common benign tumors accounting for 8Y10% of intracranial tumors and about 80% of cerebellopontine tumors. Histologically, VSs arise from the sheath of the eight nerve. These tumors generally grow slowly, causing minimal symptoms at the time of diagnosis. The growth rate of VS is known to be extremely variable, with most tumors showing slow growth for many years.

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