Time course of Early Metabolic Changes following Diffuse Traumatic Brain Injury in Rats as detected by H NMR Spectroscopy
Autores: J.M. Pascual - Juan Solivera - Ruth Prieto - Laura Barrios - Pilar Lopez-Larrubia - Sebastian Cerdan - J.M. Roda
Abstract: Experimental models of traumatic brains injury (TBI) provide a useful tool for understanding the cerebral metabolic changes induced by this pathological condition.
Here, we report on the timecourse of changes in cerebral metabolites after TBI and its correlation with early brain morpho-logical changes using a combination of high-resolution proton magnetic resonance spectroscopy (1HMRS) and magnetic resonance imaging (MRI). Adult male Sprague-Dawley rats were subjected toclosed head impact and examined by MRI at 1, 9, 24, 48, and and 72 h after the injury ...