Transcription of the NR1 Subunit of the N-Methyl- d-aspartate receptor is down-regulated by Exitotoxic stimulation and cerebral ischemia.

Autores: Sergio Gascon - Ruben Deogracias - Monica Sobrado - J.M. Roda - Jaime Renart - Angeles Rodriguez-Peña - Margarita Diaz-Guerra

Abstract: The N-Methyl-d-aspartate type of glutamate receptor plays central roles

Read Document

Exitotoxicity and focal cerebral ischemoa induce truncation of the NR2A and NR2B subunitis of the NMDA receptor and cleavage of the scaffolding protein PSD-95

Autores: S. Gascon - M. Sobrado - J.M. Roda - A. Rodriguez-Peña - M. Diaz-Guerra

Abstract: The N-Methyl-D-aspartate type of glutamate receptor (NMDAR) plays key roles in neuronal plasticity, learning and memory in the central nervous system, fundamentally due to its high Ca2+ permeability.

Read Document

Glutamate, glutamine, and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats.

Autores: J.M. Pascual - Fernando Carceller - J.M. Roda -  Sebastian Cerdan

Abstract: Some of the metabolic mechanisms underlying the devel-opment of ischemic brain damage have been investigated using highly enriched cultures of neural cells1– 4or cerebral cortex slices. However, the metabolic events occurring in vivo in the neuronal and glial compartments of the adult brain during the development of ischemic damage remain less understood. ...

Read Document PDF