Parada et al 2019 British Journal of Pharmacology

Inflammation takes place in both chronic and acute brain diseases and plays a key role in the development of several pathologies.

Autores: Esther Parada - Ana I. Casas - Alejandra Palomino‐Antolin - Vanessa Gómez‐Rangel - Alfonso Rubio‐Navarro - Victor Farré‐Alins - Paloma Narros‐Fernandez - Melania Guerrero‐Hue - Juan Antonio Moreno - Juliana M. Rosa - J.M. Roda - Borja J. Hernández‐García - Javier Egea

Abstract: Indeed, immune activation in the CNS is a common feature of brain injuries such as stroke, neurodegenerative diseases, and multiple sclerosis. Chronic inflammation leads to noxious effects on neurons and, thus,contributes to the pathophysiology of neurodegenerative diseases.Brain ischaemia is an acute injury that leads to the production of ROS and reactive nitrogen species (RNS), lipid peroxidation, blood–brain barrier (BBB) disruption, and exacerbated inflammation resultingin dramatic neuronal death ...

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