Small Synthetic Hyaluronan Disaccharides Afford Neuroprotection in Brain Ischemia-Related models

Bases Anatomicas y Hemodinamicas del complejo de la arteria comunicante anterior.

Autores: J. Egea - E. Parada - V. Gomez-Rangel - I. Buendia - P. Negredo - E. Montell - R. Ruhí - J. Vergés - J.M. Roda - A.G. Garcia - M.G. Lopez

Abstract: —High molecular weight (HMW) glycosaminoglycanes of the extracellular matrix have been implicated in tissue repair.

Stroke is the third leading cause of death, behind cardiovascular diseases and cancer, and is a leading cause of serious, long-term disability. Although treatments for ischemic stroke have been rigorously investigated for two decades, up to now there is only one approved pharmacological treatment, the intravenous thrombolytic recombinant tissue plasminogen activator (rt-PA) (Jahan and Vinuela,2009). Despite the fact that thrombolytic rt-PA hasdemonstrated efficacy in treating patients withthrombotic stroke, the short time window, the risk ofhemorrhage and the requirement for computedtomography scan before the initiation of treatmentreduces the number of patients (around 4%) actuallyreceiving the drug; consequently, other approaches totreat stroke are urgently needed.

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