Functional recovery after hematic administration of allogenic mesenchimal stem cells in acute schemic stroke in rates.
Autores: M. Gutierrez-Fernandez - B. Rodriguez-Frutos - J. Alvarez-Grech - M.T. vallejo-Cremades - M. Exposito-Alcaide - J. Merino - J.M. Roda - E. Diez-Tejedor
Abstract: The majority of neuroprotective treatments for cerebral ischemia have been efficacious in experimental studies but have failed their clinical trials. Only i.v. thrombolysis (rtPA) hasbeen shown to be effective; however its narrow therapeutictime window makes it a treatment for a reduced percentageof patients (Hacke et al., 2008). In the past, protective ther-apies have been directed towards saving neural cells. Stroke-induced damage compromises the integrity of the neurovas-cular unit (Lo et al., 2003) through various pathophysiologicmechanisms. Angiogenesis, neurogenesis and synaptogen-esis are interrelated mechanisms that promote brain plasticityand help to repair the neurovascular unit and recover neuro-logical function (Gutierrez et al., 2009). Endogenous brainplasticity can be stimulated by rehabilitation, stimulationand/or administration of trophic factors and cell therapy.