Seven Microaneurysms: Description of an Experimental Rodent Model for Neurovascular Training

AIM: To demonstrate the microsurgical procedures, and to evaluate the feasibility of living models of experimental neurovascular training by developing new complex vascular exercises mimicking the most common intracranial aneurysms.

MATERIAL and METHODS: The procedures were performed under a Zeiss (OPMI pico f170) microscope using basic microsurgery instruments, 10/0 Nylon and blue Polypropylene micro-sutures. We selected adult albino Wistar rats weighing between 258 and 471g each. Seven different aneurysm types were created using carotid, jugular, cava, aorta and femoral vessels ...


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The Experience of a Facial Nerve Unit in the Treatment of Patients With Facial Paralysis Following Skull Base Surgery

The management of facial paralysis following skull base surgery is complex and requires multidisciplinary intervention.

This review shows the experience of a facial nerve (FN) unit in a tertiary university referral center ...

Authors: Luis Lassaletta, José Manuel Morales-Puebla, Teresa Gonzalez-Otero, Susana Moraleda, Jose María Roda , Javier Gavilan.

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Assessment of Pre-operative Measurements of Tumor Size by MRI Methods as Survival Predictors in Wild Type IDH Glioblastoma

Objective: We evaluate the performance of three MRI methods to determine non-invasively tumor size, as overall survival (OS) and Progression Free Survival (PFS) predictors, in a cohort of wild type, IDH negative, glioblastoma patients. Investigated protocols included bidimensional (2D) diameter measurements, and three-dimensional (3D) estimations by the ellipsoid or semi-automatic segmentation methods.

Authors: Alexis Junnior Palpan Flores, Catalina Vivancos Sanchez, Jose María Roda , Sebastian Cerdan, Andres Javier Barrios, Cristina Utrilla, Aranzazu Royo, Maria Luisa Gandía-González

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Congratulations on the publication of your article: Assessment of Pre-operative Measurements of Tumor Size by MRI Methods as Survival Predictors in Wild Type IDH Glioblastoma, by Alexis Junnior Palpan Flores, Catalina Vivancos Sanchez, Jose María Roda, Sebastian Cerdan, Andres Javier Barrios, Cristina Utrilla, Aranzazu Royo, Maria Luisa Gandía-González, published in Frontiers in Oncology, section Neuro-Oncology and Neurosurgical Oncology.

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The use of transcranial motor-evoked potentials …

The use of transcranial motor-evoked potentials, somatosensory-evoked potentials and free-run electromyography for proper placement of paddle leads in chronic pain

Authors: José F. Paz, María del Mar Santiago Sanz, María Victoria Paz-Domingo, María Luisa Gandía-González, Susana Santiago-Pérez, Jose María Roda Frade

As an alternative to those patients who cannot be performed an awake spinal cord stimulation (SCS) or had been percutaneously implanted with poor pain relief outcomes, neurophysiological monitoring through transcranial motor evoked potentials (MEPs), somatosensory-evoked potentials (SSEPs) and free-run electromyography (EMG) under general anesthesia allows the correct placement of surgical leads and provide objective responses.

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Neurosurgeons on the frontline of COVID-19: no place for surgery?

Dear Editor

We read with interest the report by Zoia, and we would like to widen the picture by sharing our experience in Madrid’s COVID-19 reference center, one of the hardest hit areas in Europe. As neurosurgeons, we never would have imagined being in the eye of the storm. We hope our humble experience can be helpful to colleagues in other countries.

Authors: Maria L. Gandía-González, Miguel Sáez-Alegre, José M. Roda

On 27 April 2020, Spain represented the hardest hitEuropean country by the COVID-19 pandemic with 219,764cases and 48.2 deaths per 100,000 inhabitants. Madrid becamethe epicenter of the outbreak, with 59,126 cases diagnosed,and a death toll of 7,922 hospitalized victims.

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Facial nerve repair: the impact of technical variations on the final outcome

The impact of technical variations on the final outcome

Autores: María Sánchez-Ocando - Javier Gavilán - Julio Penarrocha - Teresa González-Otero - Susana Moraleda -
José María Roda - Luis Lassaletta

Abstract: Objectives To analyze the outcome of facial nerve (FN) reconstruction, the impact of technical variations in different conditions and locations, and the importance of additional techniques in case of suboptimal results.

Patients Between 2001 and 2017, reconstruction of the FN was performed on 36 patients with varying underlying diseases. Interventions FN repair was performed by direct coaptation (n = 3) or graft interposition (n = 33). Microsurgical sutures were used in 17 patients (47%) and fibrin glue was used in all cases. Additional reinnervation techniques (hypoglossal–facial or masseter–facial transfers) were performed in five patients with poor results after initial reconstruction.

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Assessment of Overall Survival in Glioma Patients as Predicted by Metabolomic Criteria

We assess the efficacy of the metabolomic profile from glioma biopsies in providing estimates of postsurgical Overall Survival in glioma patients.

Autores: María L. Gandía-González - Sebastián Cerdán - Laura Barrios - Pilar López-Larrubia - Pablo G. Feijoó - Alexis Palpan Jr. - José M. Roda - Juan Solivera

Abstract: Tumor biopsies from 46 patients bearing gliomas, obtained neurosurgically in the period 1992–1998, were analyzed by high resolution 1H magnetic resonance spectroscopy (HR- 1H MRS), following retrospectively individual postsurgical Overall Survival up to 720 weeks.

The Overall Survival profile could be resolved in three groups; Short (shorter than 52 weeks, n = 19), Intermediate (between 53 and 364 weeks, n = 19) or Long (longer than 365 weeks, n = 8), respectively. Classical histopathological analysis assigned WHO grades II–IV to every biopsy but notably, some patients with low grade glioma depicted unexpectedly Short Overall Survival, while some patients with high grade glioma, presented unpredictably Long Overall Survival. To explore the reasons underlying these different responses, we analyzed HR-1H MRS spectra from acid extracts of the same biopsies

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Parada et al 2019 British Journal of Pharmacology

Inflammation takes place in both chronic and acute brain diseases and plays a key role in the development of several pathologies.

Autores: Esther Parada - Ana I. Casas - Alejandra Palomino‐Antolin - Vanessa Gómez‐Rangel - Alfonso Rubio‐Navarro - Victor Farré‐Alins - Paloma Narros‐Fernandez - Melania Guerrero‐Hue - Juan Antonio Moreno - Juliana M. Rosa - J.M. Roda - Borja J. Hernández‐García - Javier Egea

Abstract: Indeed, immune activation in the CNS is a common feature of brain injuries such as stroke, neurodegenerative diseases, and multiple sclerosis. Chronic inflammation leads to noxious effects on neurons and, thus,contributes to the pathophysiology of neurodegenerative diseases.Brain ischaemia is an acute injury that leads to the production of ROS and reactive nitrogen species (RNS), lipid peroxidation, blood–brain barrier (BBB) disruption, and exacerbated inflammation resultingin dramatic neuronal death ...

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Facial paralysis

Facial paralysis: Clinical practice guide line of the Spanish Society of Otolaryngology (ORL).

Autores: Luis Lassaletta - José Manuel Morales-Puebla - Xabier Altuna - Álvaro Arbizu - Miguel Arístegui - Ángel Batuecas - Carlos Cenjor - Juan Manuel Espinosa-Sánchez - Leire García-Iza - Pilar García-Raya - Teresa González-Otero - Manuel Mañós - Carlos Martín - Susana Moraleda - Jose Maria Roda - Susana Santiago - Jesús Benítez - Laura Cavallé - Victor Correia - Jose Manuel Estévez - Justo Gómez - Rocío González - Jorge Jiménez - Jose Luis Lacosta - María José Lavilla - Julio Peñarrocha - Rubén Polo - Francisco García-Purriños - Francisco Ramos - Manuel Tomás - María Uzcanga - Luis Ángel Vallejo - Javier Gavilán

Abstract: Abstract Bell’s palsy is the most common diagnosis associated with facial nerve weakness or paralysis. However, not all patients with facial paresis/paralysis have Bell’spalsy. Other common causes include treatment of vestibular schwannoma, head and neck tumours, iatrogenic injuries, Herpes zoster, or trauma. The approach to each of these conditions varies widely.The purpose of this guide line is to provide clinicians with guidance on the treatment and monitoring of patients with different causes of facial paralysis.

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