We read with interest the report by Zoia, and we would like to widen the picture by sharing our experience in Madrid’s COVID-19 reference center, one of the hardest hit areas in Europe. As neurosurgeons, we never would have imagined being in the eye of the storm. We hope our humble experience can be helpful to colleagues in other countries.
Authors: Maria L. Gandía-González, Miguel Sáez-Alegre, José M. Roda
On 27 April 2020, Spain represented the hardest hitEuropean country by the COVID-19 pandemic with 219,764cases and 48.2 deaths per 100,000 inhabitants. Madrid becamethe epicenter of the outbreak, with 59,126 cases diagnosed,and a death toll of 7,922 hospitalized victims.
The impact of technical variations on the final outcome
Autores: María Sánchez-Ocando - Javier Gavilán - Julio Penarrocha - Teresa González-Otero - Susana Moraleda -
José María Roda - Luis Lassaletta
Abstract: Objectives To analyze the outcome of facial nerve (FN) reconstruction, the impact of technical variations in different conditions and locations, and the importance of additional techniques in case of suboptimal results.
Patients Between 2001 and 2017, reconstruction of the FN was performed on 36 patients with varying underlying diseases. Interventions FN repair was performed by direct coaptation (n = 3) or graft interposition (n = 33). Microsurgical sutures were used in 17 patients (47%) and fibrin glue was used in all cases. Additional reinnervation techniques (hypoglossal–facial or masseter–facial transfers) were performed in five patients with poor results after initial reconstruction.
We assess the efficacy of the metabolomic profile from glioma biopsies in providing estimates of postsurgical Overall Survival in glioma patients.
Autores: María L. Gandía-González - Sebastián Cerdán - Laura Barrios - Pilar López-Larrubia - Pablo G. Feijoó - Alexis Palpan Jr. - José M. Roda - Juan Solivera
Abstract: Tumor biopsies from 46 patients bearing gliomas, obtained neurosurgically in the period 1992–1998, were analyzed by high resolution 1H magnetic resonance spectroscopy (HR- 1H MRS), following retrospectively individual postsurgical Overall Survival up to 720 weeks.
The Overall Survival profile could be resolved in three groups; Short (shorter than 52 weeks, n = 19), Intermediate (between 53 and 364 weeks, n = 19) or Long (longer than 365 weeks, n = 8), respectively. Classical histopathological analysis assigned WHO grades II–IV to every biopsy but notably, some patients with low grade glioma depicted unexpectedly Short Overall Survival, while some patients with high grade glioma, presented unpredictably Long Overall Survival. To explore the reasons underlying these different responses, we analyzed HR-1H MRS spectra from acid extracts of the same biopsies