The impact of technical variations on the final outcome
Autores: María Sánchez-Ocando - Javier Gavilán - Julio Penarrocha - Teresa González-Otero - Susana Moraleda -
José María Roda - Luis Lassaletta
Abstract: Objectives To analyze the outcome of facial nerve (FN) reconstruction, the impact of technical variations in different conditions and locations, and the importance of additional techniques in case of suboptimal results.
Patients Between 2001 and 2017, reconstruction of the FN was performed on 36 patients with varying underlying diseases. Interventions FN repair was performed by direct coaptation (n = 3) or graft interposition (n = 33). Microsurgical sutures were used in 17 patients (47%) and fibrin glue was used in all cases. Additional reinnervation techniques (hypoglossal–facial or masseter–facial transfers) were performed in five patients with poor results after initial reconstruction.
We assess the efficacy of the metabolomic profile from glioma biopsies in providing estimates of postsurgical Overall Survival in glioma patients.
Autores: María L. Gandía-González - Sebastián Cerdán - Laura Barrios - Pilar López-Larrubia - Pablo G. Feijoó - Alexis Palpan Jr. - José M. Roda - Juan Solivera
Abstract: Tumor biopsies from 46 patients bearing gliomas, obtained neurosurgically in the period 1992–1998, were analyzed by high resolution 1H magnetic resonance spectroscopy (HR- 1H MRS), following retrospectively individual postsurgical Overall Survival up to 720 weeks.
The Overall Survival profile could be resolved in three groups; Short (shorter than 52 weeks, n = 19), Intermediate (between 53 and 364 weeks, n = 19) or Long (longer than 365 weeks, n = 8), respectively. Classical histopathological analysis assigned WHO grades II–IV to every biopsy but notably, some patients with low grade glioma depicted unexpectedly Short Overall Survival, while some patients with high grade glioma, presented unpredictably Long Overall Survival. To explore the reasons underlying these different responses, we analyzed HR-1H MRS spectra from acid extracts of the same biopsies
Inflammation takes place in both chronic and acute brain diseases and plays a key role in the development of several pathologies.
Autores: Esther Parada - Ana I. Casas - Alejandra Palomino‐Antolin - Vanessa Gómez‐Rangel - Alfonso Rubio‐Navarro - Victor Farré‐Alins - Paloma Narros‐Fernandez - Melania Guerrero‐Hue - Juan Antonio Moreno - Juliana M. Rosa - J.M. Roda - Borja J. Hernández‐García - Javier Egea
Abstract: Indeed, immune activation in the CNS is a common feature of brain injuries such as stroke, neurodegenerative diseases, and multiple sclerosis. Chronic inflammation leads to noxious effects on neurons and, thus,contributes to the pathophysiology of neurodegenerative diseases.Brain ischaemia is an acute injury that leads to the production of ROS and reactive nitrogen species (RNS), lipid peroxidation, blood–brain barrier (BBB) disruption, and exacerbated inflammation resultingin dramatic neuronal death ...